Rutgers scientists discover 'Legos of life'
by Staff Writers
New Brunswick NJ (SPX) Jan 24, 2018
Rutgers scientists have found the "Legos of life" - four core chemical structures that can be stacked together to build the myriad proteins inside every organism - after smashing and dissecting nearly 10,000 proteins to understand their component parts.
The four building blocks make energy available for humans and all other living organisms, according to a study published online in the Proceedings of the National Academy of Sciences.
The study's findings could lead to applications of these stackable, organic building blocks for biomedical engineering and therapeutic proteins and the development of safer, more efficient industrial and energy catalysts - proteins and enzymes that, like tireless robots, can repeatedly carry out chemical reactions and transfer energy to perform tasks.
"Understanding these parts and how they are connected to each other within the existing proteins could help us understand how to design new catalysts that could potentially split water, fix nitrogen or do other things that are really important for society," said Paul G. Falkowski, study co-author and a distinguished professor who leads the Environmental Biophysics and Molecular Ecology Laboratory at Rutgers University-New Brunswick.
The scientists' research was done on computers, using data on the 3D atomic structures of 9,500 proteins in the RCSB Protein Data Bank based at Rutgers, a rich source of information about how proteins work and evolve.
"We don't have a fossil record of what proteins looked like 4 billion years ago, so we have to take what we have today and start walking backwards, trying to imagine what these proteins looked like," said Vikas Nanda, senior author of the study and an associate professor in the Department of Biochemistry and Molecular Biology at Rutgers' Robert Wood Johnson Medical School, within Rutgers Biomedical and Health Sciences.
"The study is the first time we've been able to take something with thousands of amino acids and break it down into reasonable chunks that could have had primordial origins."
The identification of four fundamental building blocks for all proteins is just a beginning. Nanda said future research may discover five or 10 more building blocks that serve as biological Legos.
"Now we need to understand how to put these parts together to make more interesting functional molecules," he said.
"That's the next grand challenge."
Berkeley CA (SPX) Jan 11, 2018
Two wayward space rocks, which separately crashed to Earth in 1998 after circulating in our solar system's asteroid belt for billions of years, share something else in common: the ingredients for life. They are the first meteorites found to contain both liquid water and a mix of complex organic compounds such as hydrocarbons and amino acids. A detailed study of the chemical makeup within t ... read more
Lands Beyond Beyond - extra solar planets - news and science
Life Beyond Earth
|The content herein, unless otherwise known to be public domain, are Copyright 1995-2024 - Space Media Network. All websites are published in Australia and are solely subject to Australian law and governed by Fair Use principals for news reporting and research purposes. AFP, UPI and IANS news wire stories are copyright Agence France-Presse, United Press International and Indo-Asia News Service. ESA news reports are copyright European Space Agency. All NASA sourced material is public domain. Additional copyrights may apply in whole or part to other bona fide parties. All articles labeled "by Staff Writers" include reports supplied to Space Media Network by industry news wires, PR agencies, corporate press officers and the like. Such articles are individually curated and edited by Space Media Network staff on the basis of the report's information value to our industry and professional readership. Advertising does not imply endorsement, agreement or approval of any opinions, statements or information provided by Space Media Network on any Web page published or hosted by Space Media Network. General Data Protection Regulation (GDPR) Statement Our advertisers use various cookies and the like to deliver the best ad banner available at one time. All network advertising suppliers have GDPR policies (Legitimate Interest) that conform with EU regulations for data collection. By using our websites you consent to cookie based advertising. If you do not agree with this then you must stop using the websites from May 25, 2018. Privacy Statement. Additional information can be found here at About Us.