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Alcoholism drug may help design HIV cure: study
by Staff Writers
Paris (AFP) Nov 16, 2015


Terror fight squeezes anti-AIDS funds: UN official
Panama City (AFP) Nov 17, 2015 - The top UN anti-AIDS official warned Tuesday that the growing fight against terrorism risks squeezing budgets for scientists who hope to stamp out the disease within years.

UNAIDS executive director Michel Sidibe said that as countries invest in security to counter threats such as what he called last week's "barbaric" attacks in Paris, AIDS research funding risks getting cut.

"I am scared because of the crisis, the migrant population, all the problems of security, terrorism," he told AFP during a visit to Panama.

"To focus, rightly, on those issues could really take some resources out of social and development programs."

UNAIDS and other bodies estimate that of the 314 million people affected by humanitarian crises worldwide, some 1.6 million have HIV, the virus that causes AIDS.

Sidibe said the victims of such crises were even more vulnerable since some of them interrupt their AIDS treatment when they are displaced.

He expressed hope that HIV will be practically eliminated as a public health threat.

"I would not be surprised... that in probably in 10-15 years we will be able to have a functional cure or vaccine," Sidibe said.

But the UN warns that in order to do so by 2030, $32 billion a year will be needed over the next four years.

"The biggest problem, to be honest, to have a vaccine, is that we are seeing a reduction in research funds.

"Any time the world has faced major security issues, of course, the priorities will be how to address the problem of security," Sidibe said.

"Unfortunately the implicit impact is that investments and attention that should go to social sectors, particularly health and education, will be reduced, and we need to make sure that doesn't happen."

A treatment for alcoholism can reactivate dormant HIV, potentially allowing other drugs to spot and kill the virus hiding out in human immune cells, researchers said Tuesday.

The medication, called Disulfiram, draws out the AIDS-causing virus without any side effects for patients, according to a study published in The Lancet.

In people undergoing treatment for AIDS, the virus can take cover in certain cells and hide away, only to reemerge once therapy is stopped.

This latency has been one of the biggest hurdles in developing a cure.

"Waking up" the virus - and then destroying it -- is a promising strategy for ridding patients of HIV.

But other drugs which are able to rouse HIV from its dormant state are toxic to humans.

In clinical trials led by Sharon Lewin, a professor at the University of Melbourne, 30 people on antiretroviral treatment (ART) were given increasing doses of Disulfiram over a period of three days.

At the highest dose, there was evidence of slumbering HIV being stimulated, with no side effects.

"This trial clearly demonstrates that Disulfiram is not toxic and is safe to use, and could quite possibly be the game changer we need," Lewin said in a statement.

The next step will be to test Disulfiram's rousing effect in combination with a virus-killing drug.

"Waking up the virus is only the first step to eliminating it," said the study's lead author Julian Elliott, head of clinical research in the department of infectious diseases at Alfred Hospital in Melbourne, Australia.

"Now we need to work out how to get rid of the infected cell."

Approximately 34 million people have died of HIV-related causes worldwide. By the end of 2014, there were an estimated 36.9 people living with HIV globally.


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