. 24/7 Space News .
Report Of Early-Stage Human Clone Changes Face Of Biotechnology

Advanced Cell Technology�s (ACT) cell therapy programs are built upon a new class of cells able to form virtually every cell type in the body. This technology platform therefore has unusually broad applications in medicine. These primordial stem cells include Embryonic Stem (ES) cells and other cells from the Inner Cell Mass (ICM) of preimplantation embryos. The biotechnology industry hopes to produce many new therapies from these cells, for instance, neurons for the treatment of Parkinson�s disease and spinal cord injury, heart muscle cells for heart failure, cartilage for arthritis, pancreatic cells for diabetes, as well as many others. As promising as ES cell technology may seem, it does not solve the critical problem of histocompatibility. Human ES cells obtained from embryos derived during in vitro fertilization procedures, or from fetal sources, are essentially cells from another individual (allogeneic). This means that they, or any cells made from them, would be at risk of being rejected if transplanted into a human being. To solve this problem, ACT is performing research on three means to manufacture embryonic cells identical to a human adult, this is to say, autologous embryonic cells. ACT graphic


 Washington (AFP) Nov 25, 2001
US biotechnology researchers announced Sunday they had successfully created an early-stage human embryo, paving the way for future harvesting of stem cells to treat disease.

The announcement sparked another debate on the controversial medical procedure.

The Massachusetts-based Advanced Cell Technology (ACT) said in a paper to be available Monday in the Journal of Regenerative Medicine that it had effectively cloned early-stage embryos by performing somatic nuclear cell transfers.

"If the human cells behave as animal cells have in previous studies, we may have found a means of rebuilding the lifespan of cells at the same time," Michael West, the chief executive officer of ACT, said in a statement.

"This would allow us to supply young cells of any kind, identical to the patient, that could be used to address the tidal wave of age-related disease that will accompany the aging of the population."

The nuclei of donor eggs were extracted and replaced with adult human skin cells that were coaxed to activate then divide, forming a blastocyst -- a hollow ball of roughly 100 cells that holds a clump of stem cells, the building blocks of all organ and tissue cells within the body.

The researchers, however, were as yet unable to grow the inner cell mass of stem cells to yield the building block cells in humans, though they have had measured success in other animals.

"We intended to isolate human stem cells from the blastocysts to serve as the starter stock for growing replacement ... tissues," the researchers said in an analysis of their work in Scientific American.

"Unfortunately, only one of the embryos progressed to the six-cell stage, at which point it stopped dividing."

They also achieved measured success in a related experiment, creating early-stage embryos from eggs not fertilized with sperm cells.

Known as parthenogenesis, the Greek word for "virgin birth," it allows eggs to develop without fertilization, thereby simplifying the process of developing cloned embryos.

"We've taken the first halting steps toward what we call a new era in medicine," West told NBC's "Meet the Press" Sunday, noting the developments were likely to be scrutinized both by scientists and politicians trying to establish biotechnology standards to meet both medical, and moral, criteria.

"There's one big variable here, and that's the US Congress," with the House of Representatives already voting to "criminalize even the medical uses of cloning," West told CNN's "Late Edition."

White House spokeswoman Jennifer Millerwise stressed that US President George W. Bush has "made it clear 100 percent that he is opposed to any type of human cloning,"

Millerwise said the president, who in early August authorized limited federal funding for research on a select group of stem cell lines, gave his full support to the House bill, and suggested the US Senate do the same.

"He supported the House legislation to ban human cloning, and although the Senate has a busy calendar, this shows why it is important for the Senate to act," she told AFP.

"People are concerned about the ethical problems here," said Republican Senator Richard Shelby of Alabama on NBC's "Meet the Press." "Where does biomedical research lead to in the future? Will we just create test-tube babies everywhere?"

"We, in the Senate, have to draw that line so it's a reasonable line, so we can continue medical science and breakthroughs, without crossing that line into something none of us want to see," added Illinois Democrat Dick Durbin on CNN.

Reaction from the Vatican was muted, with Archbishop Tarcisio Bertone, the Holy See's secretary of the Congregation for the Doctrine of the Faith, prioritizing the need for further information.

Bertone said if a stem cell was extracted and added to an egg to genetically reprogram it, creating an embryo which was then destroyed, "then that is true human cloning, and that must be condemned."

But if ACT created stem cells from other, non-embryonic stem cells, "then we are talking about a veritable scientific achievement that we could see as ethically positive," he added.

West emphasized ACT's focus was to create embryos for therapeutic, not reproductive purposes, insisting if the procedure were declared illegal, "we wouldn't do it."

"We are just trying to help people who are sick," West insisted. "We're not talking about a little embryo with hands and feet. We're talking about a cluster of cells."

Related Links
Advanced Cell Technology
SpaceDaily
Search SpaceDaily
Subscribe To SpaceDaily Express



Memory Foam Mattress Review
Newsletters :: SpaceDaily :: SpaceWar :: TerraDaily :: Energy Daily
XML Feeds :: Space News :: Earth News :: War News :: Solar Energy News


Nebraska Chemists Create First Plastic Magnets
Lincoln - Nov. 25, 2001
A team of chemists at the University of Nebraska-Lincoln have created the world's first plastic magnets. It took 13 years of painstaking investigation, but Andrzej Rajca, a professor of chemistry, Suchada Rajca, his wife and research partner as a research assistant professor at Nebraska, and doctoral candidate Jirawat Wongsriratanakul finally achieved success earlier this year.







  • Bush Appoints Bean Counter In Bid To Salvage NASA From ISS Overruns
  • NASA Seeks Volunteers For Month-Long Bed Rest Study
  • World Space Week: A Celebration of Space Exploration
  • Consolidated Space Operations Contract: Evaluating and Reporting Cost Savings

  • Europe Heads for Mars
  • Evidence Of Martian Life Dealt Critical Blow
  • Australian Mars Research Facility Needs $250,000
  • Odyssey Begins Main Aerobraking Phase

  • Canada's First Space Telescope to Ride a "Rockot"
  • Space Communications, Khrunichev To Cooperate
  • DirecTV Sat To Launch Monday
  • ESA Clears Russian Rockets For Kourou Launches

  • Envisat No. 1 -- Europe's Environment Satellite
  • New views of Earth
  • DigitalGlobe Successfully Launches QuickBird Imaging Satellite
  • Canadian Space Agency Investing in Hyperspectral

  • Into The Deep Space Of Nowhere
  • Into The Deep Space Of Nowhere
  • Out To The Horizon Of Sol
  • Out To The Horizon Of Sol

  • Shuttle Ready To Collide With Some Dust
  • Into The Deep Space Of Nowhere
  • U.Wisconsin Gets Federal Support For IceCube
  • Fermilab Scientists Find The Gamma Without The Burst

  • Moon and Earth Formed out of Identical Material
  • Lunar Soil Yields Evidence About Sun's Dynamic Workings
  • Unique tasks for SMART-1 in exploring the Moon
  • NASA Seeks Berth On India's Moon Mission

  • Paradigm Chosen to Provide GPS-based Tracking for Highly Sensitive Security Application
  • GPS Satellite Signals Help Drivers Save Fuel and Reduce Emissions
  • Galileo Development Forges Ahead Pending Ministerial Decisions
  • TeleType Unveils Multi Tracker Device

  • The content herein, unless otherwise known to be public domain, are Copyright 1995-2006 - SpaceDaily.AFP and UPI Wire Stories are copyright Agence France-Presse and United Press International. ESA PortalReports are copyright European Space Agency. All NASA sourced material is public domain. Additionalcopyrights may apply in whole or part to other bona fide parties. Advertising does not imply endorsement,agreement or approval of any opinions, statements or information provided by SpaceDaily on any Web page published or hosted by SpaceDaily. Privacy Statement