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NANO TECH
Soft core, hard shell -- the latest in nanotechnology
by Staff Writers
Munich, Germany (SPX) Jun 28, 2015


Dr. Wolfgang G. Kreyling. Image courtesy HMGU.

Nanoparticles are the smallest particles capable of reaching virtually all parts of the body. Researchers use various approaches to test ways in which nanoparticles could be used in medicine - for instance, to deliver substances to a specific site in the body such as a tumor.

For this purpose, nanoparticles are generally coated with organic materials because their surface quality plays a key role in determining further targets in the body. If they have a water-repellent shell, nanoparticles are quickly identified by the body's immune system and eliminated.

How gold particles wander through the body
The team of scientists headed by Dr. Wolfgang Kreyling, who is now an external scientific advisor at the Institute of Epidemiology II within the Helmholtz Zentrum Muenchen, and Prof. Wolfgang Parak from the University of Marburg, succeeded for the first time in tracking the chronological sequence of such particles in an animal model. To this end, they generated tiny 5 nm gold nanoparticles radioactively labeled with a gold isotope1.

These were also covered with a polymer shell and tagged with a different radioactive isotope. According to the researchers, this was, technically speaking, a very demanding nanotechnological step.

After the subsequent intravenous injection of the particles, however, the team observed how the specially applied polymer shell disintegrated. "Surprisingly, the particulate gold accumulated mainly in the liver," Dr. Kreyling recalls. "In contrast, the shell molecules reacted in a significantly different manner, distributing themselves throughout the body."

Further analyses conducted by the scientists explained the reason for this: so-called proteolytic enzymes2 in certain liver cells appear to separate the particles from their shell. According to the researchers, this effect was hitherto unknown in vivo, since up to now the particle-conjugate had only been tested in cell cultures, where this effect had not been examined sufficiently thoroughly.

"Our results show that even nanoparticle-conjugates3 that appear highly stable can change their properties when deployed in the human body," Dr. Kreyling notes, evaluating the results. "The study will thus have an influence on future medical applications as well as on the risk evaluation of nanoparticles in consumer products and in science and technology."

1 Isotopes are types of atoms which have different mass numbers but which represent the same element.

2 Proteolytic enzymes split protein structures and are used, for example, to nourish or detoxify the body.

3 Conjugates are several types of molecules that are bound in one particle.


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Related Links
Helmholtz Zentrum Munchen - German Research Center for Environmental Health
Nano Technology News From SpaceMart.com
Computer Chip Architecture, Technology and Manufacture






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Urbana IL (SPX) Jun 16, 2015
Researchers at the University of Illinois at Urbana-Champaign have uncovered physical mechanisms allowing the manipulation of magnetic information with heat. These new phenomena rely on the transport of thermal energy, in contrast to the conventional application of magnetic fields, providing a new, and highly desirable way to manipulate magnetization at the nanoscale. "In our study, we mak ... read more


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