Subscribe free to our newsletters via your
. 24/7 Space News .




NANO TECH
Happily ever after: Scientists arrange protein-nanoparticle marriage
by Staff Writers
Buffalo NY (SPX) Apr 28, 2015


The image above illustrates how proteins (copper-colored coils) modified with polyhistidine-tags (green diamonds) can be attached to nanoparticles (red circle). Image courtesy Jonathan Lovell. For a larger version of this image please go here.

Fastening protein-based medical treatments to nanoparticles isn't easy. With arduous chemistry, scientists can do it. But like a doomed marriage, the fragile binding that holds them together often separates. This problem, which has limited how doctors can use proteins to treat serious disease, may soon change.

University at Buffalo researchers have discovered a way to easily and effectively fasten proteins to nanoparticles - essentially an arranged marriage - by simply mixing them together. The biotechnology, described April 20 online in the journal Nature Chemistry, is in its infancy. But it already has shown promise for developing an HIV vaccine and as a way to target cancer cells.

"Scientists have been able to attach proteins to nanoparticles for a while now. But it's a fairly difficult process that's only effective in a controlled environment. Nobody has been able to devise a simple method that can work inside the body," said Jonathan F. Lovell, PhD, UB assistant professor of biomedical engineering, who led the research.

He added: "We have proven that you can easily attach proteins to nanoparticles and, like Velcro that doesn't unstick, it stays together."

Additional authors include researchers from UB's Department of Chemical and Biological Engineering and Department of Microbiology and Immunology.

To create the biotechnology, the researchers use nanoparticles made of chlorophyll (a natural pigment), phospholipid (a fat similar to vegetable oil) and cobalt (a metal often used to prepare magnetic, water-resistant and high-strength alloys).

The proteins, meanwhile, are modified with a chain of amino acids called a polyhistidine-tag. Uncommon in medicine, polyhistidine-tags are used extensively in protein research.

Next, the researchers mixed the modified proteins and nanoparticles in water. There, one end of the protein embeds into the nanoparticle's outer layer while the rest of it sticks out like a tentacle.

To test the new binding model's usefulness, the researchers added to it an adjuvant, which is an immunological agent used to enhance the efficacy of vaccines and drug treatments. The results were impressive. The three parts - adjuvant, protein and nanoparticle - worked together to stimulate an immune response against HIV.

The researchers also tested proteins that target cancer cells. Again, the results were exciting, with the new binding model acting like a homing missile to tumors. The targeted nanoparticles have the potential to improve cancer treatment by targeting specific cancer cells in lieu of releasing anti-cancer drugs everywhere in the body.

Lovell plans to follow up the research with more rigorous testing of the vaccine and tumor-targeted technologies. Moving to human clinical trials is the ultimate goal.


Thanks for being here;
We need your help. The SpaceDaily news network continues to grow but revenues have never been harder to maintain.

With the rise of Ad Blockers, and Facebook - our traditional revenue sources via quality network advertising continues to decline. And unlike so many other news sites, we don't have a paywall - with those annoying usernames and passwords.

Our news coverage takes time and effort to publish 365 days a year.

If you find our news sites informative and useful then please consider becoming a regular supporter or for now make a one off contribution.

SpaceDaily Contributor
$5 Billed Once


credit card or paypal
SpaceDaily Monthly Supporter
$5 Billed Monthly


paypal only

.


Related Links
University at Buffalo
Nano Technology News From SpaceMart.com
Computer Chip Architecture, Technology and Manufacture






Comment on this article via your Facebook, Yahoo, AOL, Hotmail login.

Share this article via these popular social media networks
del.icio.usdel.icio.us DiggDigg RedditReddit GoogleGoogle




Memory Foam Mattress Review
Newsletters :: SpaceDaily :: SpaceWar :: TerraDaily :: Energy Daily
XML Feeds :: Space News :: Earth News :: War News :: Solar Energy News





NANO TECH
Chemists create tiny gold nanoparticles that reflect nature's patterns
Pittsburgh PA (SPX) Apr 21, 2015
Our world is full of patterns, from the twist of a DNA molecule to the spiral of the Milky Way. New research from Carnegie Mellon chemists has revealed that tiny, synthetic gold nanoparticles exhibit some of nature's most intricate patterns. Unveiling the kaleidoscope of these patterns was a Herculean task, and it marks the first time that a nanoparticle of this size has been crystallized ... read more


NANO TECH
Russia Invites China to Join in Creating Lunar Station

Japan to land first unmanned spacecraft on moon in 2018

Dating the moon-forming impact event with meteorites

Japan to land probe on the moon in 2018

NANO TECH
Rover on the Lookout for Dust Devils

UAE opens space center to oversee mission to Mars

Robotic Arm Gets Busy on Rock Outcrop

Mars might have liquid water

NANO TECH
The Mysteries of Astronautics

General Dynamics Integrates NASA's SGSS Infrastructure

India Role Model in Space Science Benefiting Common Man

Space law is no longer beyond this world

NANO TECH
Xinhua Insight: How China joins space club?

Chinese scientists mull power station in space

China completes second test on new carrier rocket's power system

China's Yutu rover reveals Moon's "complex" geological history

NANO TECH
Progress Incident Not Threatening Orbital Station, Work of Crew

Russia loses control of unmanned spacecraft

Japanese astronaut to arrive in ISS in May

Liquid crystal bubbles experiment arrives at International Space Station

NANO TECH
Ariane 5 gives dual lift" to the THOR 7 and SICRAL 2 satellites

Ariane 5's first launch of 2015

Sentinel-2A payload processing begins for Vega launch in June

45th Space Wing successfully launches first-ever Turkmenistan satellite

NANO TECH
Titan's Atmosphere Useful In Study Of Hazy Exoplanets

Tau Ceti Probably not the next Earth

Astronomers join forces to speed discovery of habitable worlds

Robotically discovering Earth's nearest neighbors

NANO TECH
Fast and accurate 3-D imaging technique to track optically trapped particles

Mechanical cloaks of invisibility - without complicated mathematics

ASC Signal To Supply Globecomm With Earth Stations and Upgrades

Reducing big data using quantum theory




The content herein, unless otherwise known to be public domain, are Copyright 1995-2014 - Space Media Network. All websites are published in Australia and are solely subject to Australian law and governed by Fair Use principals for news reporting and research purposes. AFP, UPI and IANS news wire stories are copyright Agence France-Presse, United Press International and Indo-Asia News Service. ESA news reports are copyright European Space Agency. All NASA sourced material is public domain. Additional copyrights may apply in whole or part to other bona fide parties. Advertising does not imply endorsement, agreement or approval of any opinions, statements or information provided by Space Media Network on any Web page published or hosted by Space Media Network. Privacy Statement All images and articles appearing on Space Media Network have been edited or digitally altered in some way. Any requests to remove copyright material will be acted upon in a timely and appropriate manner. Any attempt to extort money from Space Media Network will be ignored and reported to Australian Law Enforcement Agencies as a potential case of financial fraud involving the use of a telephonic carriage device or postal service.