Subscribe to our free daily newsletters
. 24/7 Space News .




Subscribe to our free daily newsletters



TECH SPACE
How solids dissolve in space may enable better tablets and pills on Earth
by Melissa Gaskill for ISS Science News
Houston TX (SPX) May 26, 2016


A specially designed syringe fills the vials during setup of the investigation. Image courtesy Zin Technologies. For a larger version of this image please go here.

Anyone who has been sick before knows you want relief as quickly as possible. An investigation soon taking place aboard the International Space Station could help bring that relief by improving design of tablets used to deliver medicine into the human body. The Hard to Wet Surfaces research looks at liquid-solid interactions and how certain pharmaceuticals dissolve, which may lead to more potent and effective medicines in space and on Earth.

Dissolving a solid such as a medicine tablet involves two key factors: wettability and float effect. "Wettability is how well a liquid spreads over the surface of a solid," said principal investigator Richard Cope, who holds a doctorate in chemical engineering and is the associate engineering advisor at Eli Lilly and Company. "Float effect refers to how solids that are less dense float on the surface of a liquid."

Both factors commonly play a role in how quickly and how well a solid dissolves on Earth, and the goal of this research is to better understand each by separating their effects in microgravity. Differences in density become negligible in microgravity, so researchers expect float effect to essentially disappear.

"We hypothesize that tablets that float on Earth will dissolve more quickly in microgravity because they will not float in space. More of the surface will be in contact with the liquid," said Alison Campbell, who holds a doctorate in chemistry and is a senior research scientist at Lilly.

How microgravity may affect wettability is more of an unknown. But with many pharmaceutical ingredients considered "hard to wet," understanding microgravity's effect on this characteristic is important in the fundamental approach to dissolving these substances.

"This work is foundational," said Kenneth Savin, who holds a doctorate in organic chemistry and is an advisor in Lilly's clinical innovation group. "We're looking at a basic property - how to get a solid to dissolve."

Tablets and pills that don't dissolve easily might slow a drug's release into the body, but wettability's role in drug performance is not well understood. Results will help guide ingredient choices for future pharmaceutical formulations, improving delivery to a drug's intended target.

"Looking forward, we don't know if this particular experiment will lead to sweeping changes," said Campbell. "But it is all about building a foundation of knowledge so we can develop a better product."

Some medications seem to be less effective when taken in space. Understanding whether microgravity changes the way solids dissolve also may help explain this phenomenon.

The Center for the Advancement of Science in Space (CASIS), which manages the International Space Station U.S. National Laboratory, helped the researchers from Lilly prepare their investigation for launch.

"The liquid-solid interface is an important concept to understand," said Jonathan Volk, who holds a doctorate in chemical engineering and is the CASIS commercial innovation manager. "We hope this is just the first in this kind of work."

CASIS will continue to support the investigation by helping to maximize use of data and to develop future experiments. In the future, thanks to tiny tablets that went to space, better ones could show up in our medicine cabinets here on Earth.

Thanks for being here;
We need your help. The SpaceDaily news network continues to grow but revenues have never been harder to maintain.

With the rise of Ad Blockers, and Facebook - our traditional revenue sources via quality network advertising continues to decline. And unlike so many other news sites, we don't have a paywall - with those annoying usernames and passwords.

Our news coverage takes time and effort to publish 365 days a year.

If you find our news sites informative and useful then please consider becoming a regular supporter or for now make a one off contribution.

SpaceDaily Contributor
$5 Billed Once


credit card or paypal
SpaceDaily Monthly Supporter
$5 Billed Monthly


paypal only

.


Related Links
Center for the Advancement of Science in Space
Space Technology News - Applications and Research






Comment on this article via your Facebook, Yahoo, AOL, Hotmail login.

Share this article via these popular social media networks
del.icio.usdel.icio.us DiggDigg RedditReddit GoogleGoogle

Previous Report
TECH SPACE
Rice de-icer gains anti-icing properties
Houston TX (SPX) May 24, 2016
Rice University scientists have advanced their graphene-based de-icer to serve a dual purpose. The new material still melts ice from wings and wires when conditions get too cold. But if the air is above 7 degrees Fahrenheit, ice won't form at all. The Rice lab of chemist James Tour gave its de-icer superhydrophobic (water-repelling) capabilities that passively prevent water from freezing a ... read more


TECH SPACE
SwRI scientists discover fresh lunar craters

NASA research gives new insights into how the Moon got inked

First rocket made ready for launch at Vostochny spaceport

Supernova iron found on the moon

TECH SPACE
Potential Habitats for Early Life on Mars

Are mystery Mars plumes caused by space weather?

Opportunity takes panorama; uses wheel to scuff soil

Ancient tsunami evidence on Mars reveals life potential

TECH SPACE
Space travel now in a parachute soon available

Airbus Defence and Space starts Orion service module assembly

Interns Make Archived NASA Planetary Science Data More Accessible

Out of this world: 'Moon and Mars veggies' grow in Dutch greenhouse

TECH SPACE
China, U.S. hold first dialogue on outer space safety

Long March-7 rocket delivered to launch site

China's space technology extraordinary, impressive says Euro Space Center director

China can meet Chile's satellite needs: ambassador

TECH SPACE
International Space Cooperation Strongest in Times of Political Crises

Alexander Gerst to be Space Station commander

ISS completes 100,000th orbit of Earth: mission control

Canadian astronaut to join ISS in 2018

TECH SPACE
UK's First Spaceport Could Be Beside the Sea

SpaceX Return of Samples Marks Next Step in One-Year Mission Science

Arianespace's Soyuz is approved for its early morning liftoff on May 24

Fregat is fueled in Arianespace's FCube facility for Soyuz Flight VS15

TECH SPACE
Kepler-223 System Offers Clues to Planetary Migration

Star Has Four Mini-Neptunes Orbiting in Lock Step

Exoplanets' Orbits Point to Planetary Migration

Synchronized planets reveal clues to planet formation

TECH SPACE
How the giant magnetoelectric effect occurs in bismuth ferrite

Rice de-icer gains anti-icing properties

Combining nanotextures with Leidenfrost effect for water repellency

Precise measurements on earth ensure NASA's spacecraft work in space




Memory Foam Mattress Review
Newsletters :: SpaceDaily :: SpaceWar :: TerraDaily :: Energy Daily
XML Feeds :: Space News :: Earth News :: War News :: Solar Energy News






The content herein, unless otherwise known to be public domain, are Copyright 1995-2017 - Space Media Network. All websites are published in Australia and are solely subject to Australian law and governed by Fair Use principals for news reporting and research purposes. AFP, UPI and IANS news wire stories are copyright Agence France-Presse, United Press International and Indo-Asia News Service. ESA news reports are copyright European Space Agency. All NASA sourced material is public domain. Additional copyrights may apply in whole or part to other bona fide parties. All articles labeled "by Staff Writers" include reports supplied to Space Media Network by industry news wires, PR agencies, corporate press officers and the like. Such articles are individually curated and edited by Space Media Network staff on the basis of the report's information value to our industry and professional readership. Advertising does not imply endorsement, agreement or approval of any opinions, statements or information provided by Space Media Network on any Web page published or hosted by Space Media Network. Privacy Statement