Scientists in the department of molecular biophysics and biochemistry at Yale revealed the crystal structure of the first described enzymatic RNA - what it looks like and how it reacts - in the journal Nature.
Scott Strobel, professor and principal investigator of the study and his research team at Yale, used X-ray crystallography to image the self-splicing group-I intron and the associations it makes as it reacts. The image shows an interaction with metal ions and the alignment of the RNA molecule segments.
"The structure reveals how RNA, which is chemically very different from protein, is able to use metal ions to achieve a very similar reaction mechanism," said Scott Strobel, "This argues for an evolutionarily ancient mechanism."
Over twenty years ago scientists discovered that RNA, and not just protein, could act like an enzyme. The Nobel Prize in Chemistry in 1989 was awarded to Thomas Cech at the University of Colorado and Sidney Altman at Yale at for this revolutionary discovery.
"This is the first RNA splicing complex to be visualized in molecular detail," said Strobel. "Now we can finally see what it looks like and how it reacts."
Subscribe To SpaceDaily Express
Tiny Microbes In Greenland Glacier May Define Limits For Life On Earth
New Orleans LA (SPX) May 26, 2004
The discovery of millions of micro-microbes surviving in a 120,000-year-old ice sample taken from 3,000 meters below the surface of the Greenland glacier will be announced by Penn State University scientists on 26 May 2004 at the General Meeting of the American Society for Microbiology in New Orleans, Louisiana.
|The content herein, unless otherwise known to be public domain, are Copyright 1995-2016 - Space Media Network. All websites are published in Australia and are solely subject to Australian law and governed by Fair Use principals for news reporting and research purposes. AFP, UPI and IANS news wire stories are copyright Agence France-Presse, United Press International and Indo-Asia News Service. ESA news reports are copyright European Space Agency. All NASA sourced material is public domain. Additional copyrights may apply in whole or part to other bona fide parties. Advertising does not imply endorsement, agreement or approval of any opinions, statements or information provided by Space Media Network on any Web page published or hosted by Space Media Network. Privacy Statement All images and articles appearing on Space Media Network have been edited or digitally altered in some way. Any requests to remove copyright material will be acted upon in a timely and appropriate manner. Any attempt to extort money from Space Media Network will be ignored and reported to Australian Law Enforcement Agencies as a potential case of financial fraud involving the use of a telephonic carriage device or postal service.|